Isolation and characterization of a novel bacteriophage, ASC10, that lyses Francisella tularensis
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Francisella tularensis is an extremely infectious intracellular bacterium and the etiological agent of tularemia. Inhalation of Francisella tularensis can cause pulmonary tularemia, which has a mortality rate of 35% in the absence of treatment. Studies investigating the biology and molecular pathogenesis of Francisella tularensis have increased in the last few years especially after the U.S. Centers for Disease Control and Prevention (CDC) classified Francisella tularensis as a Category A Select Agent. In this dissertation, the identification and characterization of a novel temperate bacteriophage ...