Phosphatidylserine and antibiotic coatings for allograft bone
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Osteosarcoma is the most common type of primary bone tumor in humans. Treatment usually involves both surgical resection of the tumor and chemotherapy. Limb sparing often necessitates the use of massive bone allografts, however patients on anticancer drug regimens are at increased risk of infection, non-union and mechanical failure. The purpose of this work was to develop and test antibiotic eluting phospholipid coatings for massive bone allografts which may be useful in revision surgery for patients with osteomyelitis infection. This project was motivated by previous research performed on ...