The role of the erythrocyte and subsequent ATP release in blood flow and oxygen delivery to the human forearm during hypoxic exercise
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Hypoxia and exercise each cause ATP to be released from the erythrocyte, increasing vasodilation to match the blood flow and oxygen demands of the exercising skeletal muscle tissue (Bergfeld & Forrester, 1992; Ellsworth, 2004; Gonzalez-Alonso, Olsen, & Saltin, 2002). However, few studies have examined the extent to which ATP can be released from the erythrocyte, especially due to hypoxic exercise. We hypothesized that hypoxic exercise would cause further augmentation in erythrocyte-derived ATP release, vasodilation, and blood flow. To test this hypothesis, in 10 healthy young adults, blood ...