Integrating p300 functions in HTLV-1 transcription initiation
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The HTLV-1 provirus overcomes a repressive chromatin environment for efficient transcription of its genome. This is accomplished by the robust recruitment of the coactivator protein, p300, to the viral enhancer sites through interactions with DNA bound pCREB and the viral transactivating protein, Tax. Recruitment of p300 to the HTLV-1 promoter results in histone acetylation and nucleosome depletion from the promoter region in the presence of the histone chaperone, Nap1. To study the histone acetylation requirements for Nap1-dependent nucleosome disassembly, we utilized immobilized in vitro ...