Mechanisms of IFN-γ and ceftazidime interaction for synergistic killing of Burkholderia
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Burkholderia pseudomallei is a Gram negative, facultative intracellular pathogen which infects both phagocytes and non-phagocytes and causes severe acute infections in humans and animals. Due to its inherent resistance to many classes of antibiotics, new therapies are needed which can supplement or substitute for conventional treatments in order to combat this emerging infectious disease. We have previously shown that interferon (IFN)-γ can interact with the conventionally administered antibiotic, ceftazidime, to synergistically control intracellular bacteria burden of Burkholderia infected ...