Brush-like surface using heparin/chitosan based nanoparticles for blood-contacting applications
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With increasing applications of biomedical implants, it is crucial to develop surfaces that are blood compatible, meaning they do not induce platelet or protein adhesion. Many implants that are currently used to treat a wide range of problems have one major drawback, they can induce thrombosis. The endothelial glycocalyx plays a crucial role in preventing thrombosis. Based on this idea, we set out to develop a surface that has a brush-like structure similar to that of the endothelial glycocalyx. We developed the surface by adsorbing negatively charged heparin/chitosan polyelectrolyte complex ...