Development of methods for assessing oxidative stress caused by atmospheric aerosols
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Extensive epidemiological studies show strong associations between the exposure to atmospheric aerosol particulate matter (PM) in the size range of 0.1- 10 µm and health problems, including respiratory, atherosclerosis and cardiovascular diseases. However, the mechanisms of PM-induced toxicity are poorly understood. A leading hypothesis states that airborne PM induces harm by generating reactive oxygen species in and around human tissues, leading to oxidative stress. To improve understanding of this effect, methods including biological assays and chemical assays for assessing oxidative stress ...