Neuroinflammation in manganese neurotoxicity
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Excessive environmental or dietary exposure to the essential nutrient manganese (Mn) causes neuroinflammation, particularly in the striatial-pallidum and substantia nigra pars reticulata of the CNS, concominant in the loss of striatal dopamine and motor features resembling, but distinct from, Parkinson's disease (Newland et al., 1989, Calne et al., 1994, Perl and Olanow, 2007). Previous work in our laboratory and others has identified reactive gliosis associated with an increase expression of inducible Nitric Oxide Synthase (NOS2) inflammatory, and important inflammatory gene. Increases in NOS2 ...