The development of novel N-heterocyclic carbenes for asymmetric C-C bond forming reactions
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A variety of novel N-heterocyclic carbenes have been developed as organocatalysts for highly efficient and selective intermolecular C-C bond forming reactions. Problems associated with attaining high selectivity while retaining high efficiency in asymmetric intermolecular acyl anion pathways have been resolved through non-traditional manipulation of the catalyst architecture. In the context of the asymmetric intermolecular Stetter reaction, a new series of fluorinated triazolium salt pre-catalysts have been developed that catalyze the highly enantioselective coupling of hetaryl aldehydes and ...