Investigation of innate immunity, mucosal therapeutics and pathogenesis of select agent Burkholderia species
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Burkholderia mallei and B. pseudomallei are important human pathogens and cause the diseases glanders and melioidosis, respectively. Both organisms are gram-negative bacteria and due to their potential use as bioweapons both have been classified as category B select agents by the Centers for Disease Control and Prevention (CDC). Both bacteria are highly infectious when inhaled and are inherently resistant to many antimicrobials. The protective innate immune responses to Burkholderia infection, specifically B. mallei infection, are poorly characterized. The goal of these studies was to gain ...