Studies toward the total synthesis of lydiamycin A
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The isolation of lydiamycin A from Streptomyces lydicus (strain HKI0343) was reported by Sattler and coworkers in 2006. Lydiamycin A showed potent activity against slow-growing and pathogenic mycobacteria, suggesting a novel mode of action in comparison with existing therapeutics. In addition to having no assigned absolute configuration at C-2 and C-3, the interesting structural complexity of the thirteen-membered cyclodepsipeptide makes it an attractive synthetic target. To this date there has been two synthesis reported-- lydiamycin B (Ma 2009) and lydiamycin A (Xu and Ye 2010) but none of ...