The role of innate immunity and angiogenesis in osteosarcoma growth and metastasis
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Osteosarcoma is the most common primary bone tumor in dogs and humans. Novel therapeutics are required since a number of patients will succumb to metastatic disease. Currently, it is known that a neoplastic mass contains more than transformed cells, but requires the presence of immune cells to create a supportive environment, and endothelial cells to form blood vessels to deliver oxygen and nutrients. Not only do these cells play a role in primary tumor growth, but they create an atmosphere conducive to invasion and metastasis, the primary cause of death for osteosarcoma patients. Therefore, ...