Inflammatory modulation of synovial fibroblasts in rheumatoid arthritis
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Rheumatoid arthritis (RA) has a prevalence of 1-2% and is one of the more common causes of chronic morbidity among people over 65 years of age. It is characterized by hyperplasia of fibroblast-like synoviocytes (FLS) within the synovium and recruitment of multiple leukocyte populations that drive the inflammatory process. Although disease etiology is unknown, it is thought that both genetic and environmental factors trigger the onset of RA. A key mediator of cellular inflammation and joint destruction in rheumatoid arthritis (RA) is the presence of fibroblast-like synoviocytes (FLS), a unique ...