Molecular analysis of the genetic determinants that contribute to virulence in lineage 2 West Nile virus
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The ability of arboviruses to impart significant global disease burdens is related to the corresponding capacity of arboviruses to emerge in naïve environments or re-emerge in endemic environments. The introduction of West Nile virus (WNV) into North America was marked by rapid spread across the continent, high rates of neuroinvasive disease in humans and horses, and subsequent displacement by newer evolved genotypes. In the last 12 years, an underrepresented lineage of WNV, lineage 2 (L2) has similarly emerged from sub-Saharan Africa into areas of Europe and Russia, causing widespread neurological ...