Assessing cannabinoid permeability in a mouse dermal administration model
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Cannabinoids are extremely lipophilic substances with LogP values >5. This makes cannabinoids amenable to formulation only with hydrophobic preparations for topical administration. We sought to evaluate various oil based preparations of Δ9-tetrahydrocannabinol (THC). The starting formulation (base) did not have permeation enhancers while other formulations did. Preparations were analyzed by liquid chromatography mass spectrometry to confirm potency and chemical identity prior to study initiation. Male CD-1 mice were used in the study following guidelines of humane animal use. Animals were ...