Engineering stabilized enzymes via computational design and immobilization
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The realm of biocatalysis has significantly matured beyond ancient fermentation techniques to accommodate the demand for modern day products. Enzymatically produced goods already influence our daily lives, from sweeteners and laundry detergent to blood pressure medication and antibiotics. Protein engineering has been a major driving force behind this biorevolution, yielding catalysts that can transform non-native substrates and withstand harsh industrial conditions. Although successful in many regards, computational design efforts are still limited by the crude approximations employed in searching ...