Development and utilization of a macaque-based mammosphere culture technique for breast cancer research
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Human breast cancers are thought to commonly arise from progressive neoplastic changes to the adult stem cells within the normal mammary gland. Research in this area of breast carcinogenesis currently relies heavily on the acquisition of mammary gland stem cells from the tissues of rodents and humans. While a great deal of information has been gained utilizing these models, there remain large gaps in our knowledge of breast cancer due to certain limitations with these species. The relevance of rodents as models for human breast cancer has been brought into question by notable differences between ...