Effects of antibiotic treatment strategies on feedlot cattle resistome and microbiome
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The objective of this study was to evaluate resistome and microbiome changes in feedlot cattle exposed to commonly used antimicrobials. Sixteen pens of cattle (N=16) were randomly assigned to one of four antimicrobial treatments (n=4) resulting in a complete 2x2 factorial arrangement. The first factor was to treat Ceftiofur crystalline free acid (CCFA) to either the entire pen of animals (high dosage) or to one animal in the pen (low dosage). The second factor was the subsequent feeding of chlortetracycline (CTC) in feed to the entire pen of cattle or not administering CTC to a pen of cattle. ...