The effects of the histone chaperone and histone modifications on nucleosome structure
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The nucleosome, composed of 147-bp DNA and a histone octamer, is the basic unit of chromatin in eukaryotes, which is considered as a barrier for all DNA dependent processes. Understanding how nucleosome structure is regulated provides new insights into pivotal cellular processes. Histone modifications and histone chaperones have potential roles in the regulation of nucleosome structure. Here, I investigated the role of FACT in regulating nucleosome structure. FACT (FAcilitate Chromatin Transcription) is a conserved histone chaperone that is essential for gene transcription elongation. Our ...
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Regulation of histone reader binding by histone post-translational modifications and multi-domain crosstalk Contributor:Gatchalian, Jovylyn;
Date Submitted:2016The accessibility of eukaryotic DNA depends on the compaction of chromatin, and ultimately on the position and dynamics of nucleosomes. The nucleosome undergoes a wide array of epigenetic modifications on DNA and histones ...
Contributor:Liu, Wallace Hau;
Date Submitted:2014In eukaryotes, DNA and histones are packaged into nucleosomes, which protect the genome in the form of chromatin. Chromatin is a dynamic structure that is regulated by many proteins, including modifying complexes, remodellers, ...
Generation of site-specific ubiquitinated histones through chemical ligation and characterization of histone deubiquitinases Contributor:Al-afaleq, Nouf Omar;
Date Submitted:2016Nucleosome is the basic unit of chromatin and is composed of 147 base pairs of DNA wrapped 1.65 turns around a histone octamer of the four core histones (H2A, H2B, H3 and H4)(Luger et al., 1997). Histones are subject to ...