Determing the efficacy of Poloxamer 188 (P188) in meniscal damage prevention
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Meniscal injuries compose 15% of all knee injuries, most often sports-related. Due to the meniscus's avascular nature, healing is difficult and injury often results in a partial meniscectomy. Research has shown meniscectomies drastically decrease contact area between the femur and tibia and increase strains experienced by the meniscus. This additional strain predisposes the knee to developing post-traumatic osteoarthritis. Poloxamer 188 (P188) is a non-ionic, amphillic surfactant that may have the ability to prevent cell death through selective insertion into the cell membrane. This in turn ...