Immune response modulation using Tolfenamic Acid as an effective therapeutic for Burkholderia pseudomallei infection
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Melioidosis is a tropical, often fatal, disease caused by the aerobic, Gram-negative facultative intracellular bacterium Burkholderia pseudomallei. Despite its growing global burden and high fatality rate, little is known about the disease. Recent studies demonstrate that Cyclooxygenase-2 (COX-2) inhibition is an effective post-exposure therapeutic to pulmonary melioidosis by inhibiting the production of Prostaglandin E2 (PGE2). However, this effective treatment was conducted using an experimental COX-2 inhibitor which is not approved for human or animal use, therefore, an alternative COX-2 ...