Growth factors, oncogenes, and antioncogenes in the pathogenesis of osteopetrosis and osteosarcoma
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MAV-2(0) induced avian osteopetrosis is characterized by periosteal bone proliferation in long bones. Comprehensive cellular investigations to detect and understand factors involved in the proliferation of osteopetrosis cells have not been reported. In addition, osteopetrosis has never been shown to evolve to malignancy or neoplasia and this characteristic of the disease has not been studied. To investigate the evolution to neoplasia through the study of gene expression, canine osteosarcoma samples were also included in these investigations. cDNA probes specific for tumor suppressor genes, growth ...