The impact of shear rate and reverse flow on cardiac morphogenesis and gene expression in the embryonic zebrafish heart
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Missteps in formation of the embryonic heart can have drastic consequences, making cardiac malformations a common human birth defect. During development, biomechanical factors including shear stress and reverse flow impact cardiogenesis. Shear stress is an epigenetic biomechanical force acting upon endothelial cells. Normally, a short period of reverse flow occurs prior to atrioventricular valve formation during ventricle systole and atrial diastole. The goal of our research is to investigate how altered biomechanical forces acting on endocardial cells lead to genetic responses by the heart. The ...