Cofilin-actin rods : quantification and comparison to tau pathology in a human longitudinal aging study and developing probes to measure localization and activity of NADPH oxidase 2, a component of the prion-dependent rod inducing pathway
MetadataShow full item record
The presence of extracellular amyloid plaques composed mainly of fibrils of the β-amyloid peptide (Aβ) as well as intracellular neurofibrillary tangles composed mainly of hyperphosphorylated tau protein, are used for post-mortem confirmation of the diagnosis of Alzheimer's disease (AD). However, a shift in disease hypothesis has changed over the years. It is now generally accepted that soluble forms of Aβ oligomers and not fibrils, which are deposited in plaques, are most responsible for the synaptic loss and eventual neuronal death that accompanies AD progression. In cultured mammalian neurons, ...