Influence of anatomic valve conditions and coronary flow on aortic sinus hemodynamics
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Heart disease is the leading cause of death in the US, and aortic valve stenosis represents a significant portion of this disease. While the specific causes of stenosis are not entirely clear, its development has been strongly linked to mechanical factors such as localized solid and fluid stresses and strains, especially on the aortic side of the valve leaflets. These mechanical cues can be tied to valvular hemodynamics, however the factors regulating these hemodynamics are relatively unknown. Therefore, the overarching hypothesis of this research is that aortic valve sinus hemodynamics are ...