Combining Curcumin and Alpha-lipoic Acid to Treat Cardiometabolic Syndrome
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INTRODUCTION: Obesity is associated with increased risk of developing cardiometabolic disease characterized by decreased insulin sensitivity, positive energy balance, and cardiovascular disease. Separately, the dietary compounds curcumin (CUR) and alpha lipoic acid (ALA) increase energy expenditure and insulin sensitivity. However the efficacy of combined CUR and ALA supplementation to improve characteristics of cardiometabolic health in overweight humans has never been evaluated. METHODS: 11 overweight and sedentary adults were randomly assigned to a placebo (n=5; age: 44 ± 8 years; body mass ...