Evaluation of clinical parameters for detection of early endpoint criteria in guinea pigs experimentally infected with Mycobacterium tuberculosis
MetadataShow full item record
Tuberculosis (TB) is a global epidemic caused by the bacteria Mycobacterium tuberculosis. Despite extensive research and funding to improve diagnostic and treatment strategies, the emergence of multi drug resistant and extensively drug resistant strains of M. tuberculosis are on the rise. Vaccines present a solution to the failing diagnostic and treatment strategies by preventing incidence of disease. Guinea pigs are a common animal model to test TB vaccine candidates, but are difficult to evaluate in terms of overall health status. We hypothesized that using parameters within the complete blood ...