The physiological function and pathological significance of transient receptor potential ankyrin 1 channels in the cerebral artery endothelium
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Endothelial cell Ca²⁺ dynamics have a significant influence on cerebrovascular tone. Several transient receptor potential (TRP) channels have been shown to mediate Ca²⁺ influx in the endothelium, including TRP vanilloid 4 (TRPV4), TRPV3, and TRP ankyrin 1 (TRPA1), which activates endothelium-dependent vasodilatory pathways. High resolution Ca²⁺ techniques have allowed for the recording of unitary TRP channel Ca²⁺ influx events, called TRP sparklets, in endothelial cells where they have been found to underlie vascular function. The following studies first characterize the biophysical properties ...