The application of new methodology to complex molecule synthesis : studies toward the synthesis of pordamacrine A and liphagal
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The coevolution of organic synthesis and methodology has contributed greatly to the growth of both fields. This has been enabled by the invention of new methods during the prosecution of a synthesis in order to solve an unforeseen problem as well as by the novel application of independently developed methods to complex synthetic settings. Our own studies have encompassed both of these strategies, and we present their results herein. Our initial efforts consisted of synthetic studies towards the complex hexacyclic alkaloid pordamacrine A. This molecule presented many difficulties, ...