Studies concerning platinum-catalyzed 1,6-enyne cycloisomerizations : a unified synthetic approach to the Gelsemium alkaloids
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The development and application of transition metal-catalyzed enyne cyclization reactions is an ever growing and active area of research in modern organic synthesis. One prolific class of catalysts studied in this broad arena is that of pi-acidic metal complexes. Through further understanding of the fundamental processes of these alkynophilic metal catalysts, we are able to test new transformations in more complex settings. Presented herein are our contributions to the understanding and further implementation of Pt-catalyzed alkyne activation chemistries. In particular, we have developed a ...